Characterization of Gammaherpesvirus 68 Gene 50 Transcription
نویسندگان
چکیده
منابع مشابه
Transcription program of murine gammaherpesvirus 68.
Murine gammaherpesvirus 68 (MHV-68 [also referred to as gammaHV68]) is phylogenetically related to Kaposi's sarcoma-associated herpesvirus (KSHV [also referred to as HHV-8]) and Epstein-Barr virus (EBV). However, unlike KSHV or EBV, MHV-68 readily infects fibroblast and epithelial cell lines derived from several mammalian species, providing a system to study productive and latent infections as ...
متن کاملDisruption of gammaherpesvirus 68 gene 50 demonstrates that Rta is essential for virus replication.
Gammaherpesvirus pathogenesis is dependent on the ability of these viruses to establish a lifelong latent infection and the ability to reactivate from latency. Immediate-early genes of theses viruses are thought to be critical regulators of lytic replication and reactivation from latency. The gene 50-encoded Rta is the only immediate-early gene product that appears to be conserved among all cha...
متن کاملIdentification and initial characterization of the murine gammaherpesvirus 68 gene M3, encoding an abundantly secreted protein.
Several viruses, including members of the gammaherpesvirus family, encode proteins that are secreted into the extracellular environment. We have identified an abundant 44-kDa secreted protein that is present in the supernatant of fibroblasts infected with murine gammaherpesvirus 68 (gammaHV68; also referred to as MHV-68) but not in that of uninfected fibroblasts. Sequence analysis of the amino ...
متن کاملTick-Borne Transmission of Murine Gammaherpesvirus 68
Herpesviruses are a large group of DNA viruses infecting mainly vertebrates. Murine gammaherpesvirus 68 (MHV68) is often used as a model in studies of the pathogenesis of clinically important human gammaherpesviruses such as Epstein-Barr virus and Kaposi's sarcoma-associated herpesvirus. This rodent virus appears to be geographically widespread; however, its natural transmission cycle is unknow...
متن کاملPackaging of viral microRNAs in gammaherpesvirus 68
MicroRNAs are a characteristic of many herpesvirus genomes. These short, non-coding RNAs are capable of post-transcriptional regulation of target mRNAs. Recently, packaged miRNAs have been observed in purified virions of EBV and KSHV, gammaherpesviruses pathogenic in humans. Gammaherpesvirus 68 serves as a small-animal model of gammaherpesvirus pathogenesis. It encodes eight RNA pol III transcr...
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ژورنال
عنوان ژورنال: Journal of Virology
سال: 2000
ISSN: 0022-538X,1098-5514
DOI: 10.1128/jvi.74.4.2029-2037.2000